OCTOBER 2-3-4, 2018

Quebec City Convention Centre, Canada

SOPHIE LAYE

Director of the NutriNeuro integrated nutrition and neurobiology unit at the Inra centre in Bordeaux-Aquitaine, France/@Inra_France

“Dietary n-3 polyunsaturated fatty acid role in mood and cognitive disorders”

BIOGRAPHY

Dr. Layé is the Director of Nutrineuro Research Unit of Université de Bordeaux and co-directs the International Associated Laboratory “OptiNutriBrain”, a joint initiative with INRA, Université de Bordeaux, Bordeaux INP Aquitaine and INAF. Her research studies the effects of nutrition on the brain through experimental and clinical research designs, implicating the the development of translational approaches. She studies the role of polyunsaturated fatty acids (PUFAs) in brain function and in the affective and cognitive components of wellness and inflammation of the brain, interaction with nutritional and metabolic status.

ABSTRACT

Unbalanced intake of essential n-3 polyunsaturated fatty acid (PUFAs) is a hallmark of westernized dietary habits, which occur in both developed and developing countries. Epidemiological and clinical data suggest that the consumption of diets poor in n-3 PUA are key in several brain disorders. However, the neurobiological mechanisms underlying dietary n-3 PUFA deficiency and in brain disorders is still poorly known.

The purpose of the work conducted in our team is to understand how dietary lipids influences mood and cognitive disorders. To do so, we use state-of-art lipidomics and transcriptomics analyses, super resolution imaging, electrophysiology and behavior in mice fed with a n-3 PUFA deficient or an isocaloric n-3 PUFA balanced diet. N-3 PUFA deficient diet consumption led to a decrease in docosahexaenoic acid (DHA), the main brain n-3 PUFA, in the hippocampus, the prefrontal cortex and the nucleus accumbens. N-3 deficient mice exhibited an impairment in spatial memory and emotional behaviour (anxiety-like and social behaviour). These modifications were accompanied by a reduction of dendritic length in the hippocampus and prefrontal cortex. Emotional behavioral effects of n-3 PUFA deficiency involve changes in endocannabinoid-dependent synaptic plasticity in the nucleus accumbens. Endocannabinoids are retrograde messengers, which adjust the precise timing of neurotransmitter release from the pre-synapse, thus modulating synaptic efficacy and neuronal activity. In addition, neuroinflammatory pathways were activated in the hippocampus of n-3 PUFA mice. In particular, we found that microglia cell activity is impaired in the hippocampus, with a phagocytic activity towards synapses. Overall, dietary n-3 PUFA deficiency is a risk factor for mood and cognitive disorders through the promotion of neuroinflammation and the alteration of endocannabinoid-dependent synaptic plasticity

Implementing Partners

BÉNÉFIQ IS …
The international rendezvous on health ingredients that will be held from October 2 to 4, 2018, at the Quebec City Convention Centre in Canada. Anchored in Quebec City’s reputation for excellence in food and health, BENEFIQ is a must-attend event sparking synergy among scientists and industry professionals from this rapidly evolving sector.
An initiative of the Institute of Nutrition and Functional Foods (INAF)

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