OCTOBER 2-3-4, 2018

Quebec City Convention Centre, Canada

TED DINAN

Professor of Psychiatry and a Principal Investigator in the APC Microbiome Institute, University College Cork, Ireland / @TedDinan

“Gut microbes and brain function”

BIOGRAPHY

Ted Dinan is Professor of Psychiatry and a Principal Investigator in the APC Microbiome Institute at University College Cork. He was previously Chair of Clinical Neurosciences and Professor of Psychological Medicine at St. Bartholomew’s Hospital, London. Prior to that, he was a Senior Lecturer in Psychiatry at Trinity College Dublin. He has worked in research laboratories on both sides of the Atlantic and has a PhD in Pharmacology from the University of London. He is a Fellow of the Royal Colleges of Physicians and Psychiatrists and a Fellow of the American College of Physicians. His main research interest is in the role of the gut microbiota in stress related disorders. He has also worked extensively on the regulation of the hypothalamic-pituitary-adrenal axis. In 1995 was awarded the Melvin Ramsey Prize for research into the biology of stress. His current research is funded by Science Foundation Ireland, the Health Research Board and European Union FP7. He has published over 400 papers and numerous books on pharmacology and neurobiology. He is on the Editorial Boards of several journals.

ABSTRACT

Evidence is accumulating to suggest that gut microbes is involved in neural development and function, both peripherally in the enteric nervous system and centrally in the brain.  While evidence is still limited in psychiatric illnesses, there are rapidly coalescing clusters of evidence which point to the possibility that variations in the composition of gut microbes may be associated with changes in the normal functioning of the nervous system.

There are marked differences in the gut microbiota between patients with major depression and healthy controls.  We conducted a faecal microbiota transplant in rats with faeces from depressed patients or healthy controls.  Those rats receiving a transplant from depressed patients developed a depressive phenotype with alteration in corticosterone release and tryptophan metabolism.

That bacteria might have a positive mental health benefit is now becoming clear.  Such bacteria may influence the capacity to deal with stress, reducing anxiety, perhaps positively impacting on mood and are now called psychobiotics.  Whether, they are capable of acting like and in some circumstances replacing antidepressants remains to be seen. 

Implementing Partners

BÉNÉFIQ IS …
The international rendezvous on health ingredients that will be held from October 2 to 4, 2018, at the Quebec City Convention Centre in Canada. Anchored in Quebec City’s reputation for excellence in food and health, BENEFIQ is a must-attend event sparking synergy among scientists and industry professionals from this rapidly evolving sector.
An initiative of the Institute of Nutrition and Functional Foods (INAF)

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